Because animal reproduction studies are not always predictive of human response, Ammonium Lactate Lotion, 12% should be used during pregnancy only if clearly needed. … Lactic acid is an alpha-hydroxy acid. It also contains cetyl alcohol, fragrance, glycerin, glyceryl stearate, laureth-4, light mineral oil, magnesium aluminum silicate, methylcellulose, methylparaben, PEG-100 stearate, polyoxyl 40 stearate, propylene glycol, propylparaben, and purified water. Shake the lotion form of this medication well just before using it. Rash and peeling skin may also occur. Other reported clinical experience has not identified differences in responses between elderly and younger patients. The oral administration of ammonium lactate to rats and mice showed this drug to be practically non-toxic (LD50>15 mL/kg). Ammonium Lactate Lotion, 12% is indicated for the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris, and for the temporary relief of itching associated with these conditions. For lot number and expiration date, see bottle. The potential for post-inflammatory hypo- or hyperpigmentation has not been studied. Clinical studies of ammonium lactate lotion, 12% did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. The mutagenic potential of Ammonium Lactate formulations was evaluated in the Ames assay and in the mouse in vivo micronucleus assay, both of which were negative. Animal reproduction studies have been performed in rats and rabbits at doses up to 0.7 and 1.5 times the human dose, respectively (600 mg/kg/day, corresponding to 3600 mg/m2/day in the rat and 7200 mg/m2/day in the rabbit) and have revealed no evidence of impaired fertility or harm to the fetus due to ammonium lactate formulations. * by AmLactin Ammonium Lactate; Third Edition The oral administration of Ammonium Lactate to rats and mice showed this drug to be practically non-toxic (LD50>15 mL/kg). No unusual toxic effects were reported. Clinical studies of Ammonium Lactate lotion, 12% did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. August 22, 2012 at 2:36 pm Ammonium lactate is commonly sold over the counter by the name of amlactin, LAC lotion, or LAC hydrin. In general, dose selection for an elderly patient should be cautious. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. ammonium lactate 12 % lotion. Use twice daily or as directed by a physician. Shake well. Apply ammonium lactate at around the same time (s) every day. Lactic acid is a racemic mixture of 2-hydroxypropanoic acid and has the following structural formula: Lactic acid is an alpha-hydroxy acid, it is a normal constituent of tissues and blood. No unusual toxic effects were reported. I have been given Lac Hydrin over the years but I hate it because it stings badly if any of your skin is irritated or cracked. Other adverse reactions which occur less frequently are irritation, eczema, petechiae, dryness, and hyperpigmentation. Because animal reproduction studies are not always predictive of human response, Ammonium Lactate Lotion, 12% should be used during pregnancy only if clearly needed. The most frequent adverse experiences in patients with xerosis are transient stinging (1 in 30 patients), burning (1 in 30 patients), erythema (1 in 50 patients) and peeling (1 in 60 patients). CONTAINS: *Ammonium Lactate equivalent to 12% lactic acid, cetyl alcohol, fragrance, glycerin, glyceryl stearate, laureth-4, light mineral oil, magnesium aluminum silicate, methylcellulose, methylparaben, PEG-100 stearate, polyoxyl 40 stearate, propylene glycol, propylparaben, and purified water. The alpha-hydroxy acids (and their salts) may act as humectants when applied to the skin. Safety and effectiveness of Ammonium Lactate have been demonstrated in infants and children. Apply to the affected areas and rub in thoroughly. It also contains cetyl alcohol, fragrance, glycerin, glyceryl stearate, laureth-4, light mineral oil, magnesium aluminum silicate, methylcellulose, methylparaben, PEG-100 stearate, polyoxyl 40 stearate, propylene glycol, propylparaben, and purified water. The alpha-hydroxy acids (and their salts) may act as … For Dermatologic Use Only Ammonium lactate is usually applied twice a day. Not for Ophthalmic, Oral or Intravaginal Use. imprint No data. The mechanism(s) by which this is accomplished is not yet known. Stinging or burning may occur when applied to skin with fissures, erosions, or that is otherwise abraded (for example, after shaving the legs). The mechanism(s) by which this is accomplished is not yet known. Lac-Hydrin specially formulates 12% lactic acid, neutralized with ammonium hydroxide, as ammonium lactate to provide a lotion pH of 4.4-5.5. The following image is a placeholder representing the product identifier that is either affixed or imprinted on the drug package label during the packaging operation. Ammonium Lactate Lotion, 12% is available as follows: Store at 20-25°C (68-77°F) [see USP Controlled Room Temperature]. The potential for post-inflammatory hypo- or hyperpigmentation has not been studied. Patients using Ammonium Lactate Lotion, 12% should receive the following information and instructions: The topical treatment of CD-1 mice with 12%, 21% or 30% Ammonium Lactate formulations for two-years did not produce a significant increase in dermal or systemic tumors in the absence of increased exposure to ultraviolet radiation. Usual Dosage: Shake well. hydroxyzine, hydrocortisone topical, lidocaine topical, diphenhydramine, Benadryl, Eucerin, Aquaphor, AmLactin, dimethicone topical, CeraVe. Sun exposure (natural or artificial sunlight) to areas of the skin treated with Ammonium Lactate Lotion, 12% should be minimized or avoided (see PRECAUTIONS). Apply to the affected areas and rub in thoroughly. Get free shipping at $35 and view promotions and reviews for Amlactin Daily Moisturizing Body Lotion 12% Distributed By Perrigo, Allegan, MI 49010. Any ammonium lactate lotion will have this smell - I have used several brands with success. Other reported clinical experience has not identified differences in responses between elderly and younger patients. It is a moisturizer that is designed to treat the symptoms of dry, scaly skin conditions such as ichthyosis vulgaris and xerosis. Ammonium Lactate Lotion, 12% is contraindicated in those patients with a history of hypersensitivity to any of the label ingredients. Keep your skin looking smooth, vibrant and healthy with this Ammonium Lactate 12 Percent Cream. Ammonium Lactate Lotion, 12% is indicated for the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris, and for the temporary relief of itching associated with these conditions. AMMONIUM LACTATE- ammonium lactate lotion  Last updated on Sep 21, 2020. ➺ Common brand names: Lac-Hydrin, AmLactin, Geri-Hydrolac, LAClotion, LAC Cream, Al-12 ➺ Generic name: ammonium lactate ➺ Drug class and mechanism: It is an anti-itch prescription medicine. Caution is advised when used on the face because of the potential for irritation. This medicine is a white, lotion ‹ Back to Gallery. Ammonium Lactate Lotion, 12% is available as follows: Store at 20-25°C (68-77°F) [see USP Controlled Room Temperature]. Although lactic acid is a normal constituent of blood and tissues, it is not known to what extent this drug affects normal lactic acid levels in human milk. Other adverse reactions which occur less frequently are irritation, eczema, petechiae, dryness, and hyperpigmentation. Lotions are thinner and lighter in consistency and can be used all over the body (for example, in case of eczema). and Milwaukee, Wisconsin A double-blind, paired comparison study was used to evaluate treatment effects of 12% ammonium lactate lotion (Lac-Hydrin) against its … Because many drugs are excreted in human milk, caution should be exercised when Ammonium Lactate is administered to a nursing woman. This Ammonium Lactate cream infuses skin with moisture and smooths it out to give it a younger and healthier appearance. The following image is a placeholder representing the product identifier that is either affixed or imprinted on the drug package label during the packaging operation. The alpha-hydroxy acids (and their salts) may act as humectants when applied to the skin. Due to the more severe initial skin conditions associated with ichthyosis, there was a higher incidence of transient stinging, burning and erythema (each occurring in 1 in 10 patients). Ammonium Lactate Cream, 12% also contains cetyl alcohol, glycerin, glyceryl stearate, laureth-4, light mineral oil, magnesium aluminum silicate, methylcellulose, methylparaben, PEG-100 stearate, polyoxyl 40 stearate, propylene glycol, propylparaben, and purified water. This topical medication is made from 12% lactic acid and ammonium hydroxide. Lactic acid is a racemic mixture of 2-hydroxypropanoic acid and has the following structural formula: Lactic acid is an alpha-hydroxy acid, it is a normal constituent of tissues and blood. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Less frequently occurring side effects include irritation, dryness, eczema, changes in skin color, or small … For external use only. I think soaking is … This property may influence hydration of the stratum corneum. Ammonium Lactate Lotion, 12% is indicated for the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris, and for the temporary relief of itching associated with these conditions. I've been using it for years, including back when it was only available by prescription here. Because many drugs are excreted in human milk, caution should be exercised when ammonium lactate is administered to a nursing woman. There are, however, no adequate and well-controlled studies in pregnant women. ➺ Ammonium lactate cream is available in 280 grams (two 140 gram… In dermal Segment I and III studies with Ammonium Lactate formulations there were no effects observed in fertility or pre- or postnatal development parameters in rats at dose levels of 300 mg/kg/day (1800 mg/m2/day), approximately 0.4 times the human topical dose. In addition, lactic acid, when applied to the skin, may act to decrease corneocyte cohesion. *Ammonium Lactate Lotion, 12% specially formulates 12% lactic acid neutralized with ammonium hydroxide, as Ammonium Lactate to provide a lotion pH of 4.5 - 5.5. Animal reproduction studies have been performed in rats and rabbits at doses up to 0.7 and 1.5 times the human dose, respectively (600 mg/kg/day, corresponding to 3600 mg/m2/day in the rat and 7200 mg/m2/day in the rabbit) and have revealed no evidence of impaired fertility or harm to the fetus due to Ammonium Lactate formulations. I use it on hands, feet, knees. The mutagenic potential of ammonium lactate formulations was evaluated in the Ames assay and in the mouse in vivo micronucleus assay, both of which were negative. An in vitro study of percutaneous absorption of Ammonium Lactate lotion, 12% using human cadaver skin indicates that approximately 5.8% of the material was absorbed after 68 hours. ammonium lactate 12 % topical cream. Ammonium lactate also prevents keratinization of epidermal skin layer, which keeps skin smoother and hydrated for a longer time. color white shape No data. Ammonium Lactate Lotion, 12% is contraindicated in those patients with a history of hypersensitivity to any of the label ingredients. Ammonium Lactate Lotion 12%C-P , Fliptop - (400grams/14oz) - Pack of 2; Ammonium Lactate 12% Moisturizing Cream 140 Gm Flip-Top Tube by Major Ammonium Lactate 12% Moisturizing Cream 140 Gm Flip-Top Tube [2 PACK] AMMONIUM LACTATE 12% MOISTURIZING LOTION 226GM (8 OZ) EACH (PACK OF 2) *COMPARE TO THE SAME ACTIVE INGREDIENTS FOUND IN AMLACTIN & SAVE! Patients using Ammonium Lactate Lotion, 12% should receive the following information and instructions: The topical treatment of CD-1 mice with 12%, 21% or 30% ammonium lactate formulations for two-years did not produce a significant increase in dermal or systemic tumors in the absence of increased exposure to ultraviolet radiation. Ammonium lactate comes as a cream and a lotion to apply to the skin. Medically reviewed by Drugs.com. The maximum systemic exposure of the mice in this study was 0.7 times the maximum possible systemic exposure in humans. Amlactin Daily Moisturizing Body Lotion 12% at Walgreens. However, a long-term photocarcinogenicity study in hairless albino mice suggested that topically applied 12% Ammonium Lactate formulations enhanced the rate of ultraviolet light-induced skin tumor formation. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Many lotions and creams sting terribly and cause worse suffering, but Ammonium Lactate cream is so cooling and soothing and does not further irritate my sensitive skin. An in vitro study of percutaneous absorption of ammonium lactate lotion, 12% using human cadaver skin indicates that approximately 5.8% of the material was absorbed after 68 hours. The most frequent adverse experiences in patients with xerosis are transient stinging (1 in 30 patients), burning (1 in 30 patients), erythema (1 in 50 patients) and peeling (1 in 60 patients). Shake well. However, a long-term photocarcinogenicity study in hairless albino mice suggested that topically applied 12% ammonium lactate formulations enhanced the rate of ultraviolet light-induced skin tumor formation. It is a normal constituent of tissues and blood. Evaluation of ammonium lactate in the treatment of seborrheic keratoses Maria V. Klaus, MD,a Richard F. Wehr, BS,b Roy S. Rogers III, MD,c Thomas J. Russell, MD: and Lincoln Krochmal, MOb Buffalo, New York, Rochester, Minnesota. Set id: dc3a6462-0f2c-4306-b5ef-c7b47395e959, Not for Ophthalmic, Oral or Intravaginal Use, 225 g in 1 BOTTLE, PLASTIC; Type 0: Not a Combination Product, 400 g in 1 BOTTLE, PLASTIC; Type 0: Not a Combination Product. The maximum systemic exposure of the mice in this study was 0.7 times the maximum possible systemic exposure in humans. Select one or more newsletters to continue. This is a serious creme that provides incredible relief and promotes healing, but it is not a quick-absorb lotion so one will need gloves to help with absorption. Not for Ophthalmic, Oral or Intravaginal Use. Perrigo New York Inc, For Dermatologic Use Only There are, however, no adequate and well-controlled studies in pregnant women. For lot number and expiration date, see bottle. Stinging or burning may occur when applied to skin with fissures, erosions, or that is otherwise abraded (for example, after shaving the legs). In general, dose selection for an elderly patient should be cautious. In addition, lactic acid, when applied to the skin, may act to decrease corneocyte cohesion. Caution is advised when used on the face because of the potential for irritation. Distributed By Perrigo, Allegan, MI 49010. *Ammonium Lactate Lotion, 12% specially formulates 12% lactic acid neutralized with ammonium hydroxide, as ammonium lactate to provide a lotion pH of 4.5 - 5.5. CONTAINS: *Ammonium lactate equivalent to 12% lactic acid, cetyl alcohol, fragrance, glycerin, glyceryl stearate, laureth-4, light mineral oil, magnesium aluminum silicate, methylcellulose, methylparaben, PEG-100 stearate, polyoxyl 40 stearate, propylene glycol, propylparaben, and purified water. Ammonium lactate hydrates the outermost skin layer and promotes skin moisturizing for a prolonged time. The use of Ammonium Lactate Lotion, 12% should be discontinued if any hypersensitivity is observed. * by AmLactin Ammonium Lactate… Not for Ophthalmic, Oral or Intravaginal Use, We comply with the HONcode standard for trustworthy health information -, Lactic Acid and Ammonium Hydroxide Lotion. Due to the more severe initial skin conditions associated with ichthyosis, there was a higher incidence of transient stinging, burning and erythema (each occurring in 1 in 10 patients). Sadly, a small percentage of you may experience a negative reaction to the lotion. Use twice daily or as directed by a physician. Usual Dosage: Shake well. But the smell dissipates, and for many, it truly helps heal dry skin. ➺ It is available in the form of cream as well as lotion. Safety and effectiveness of ammonium lactate have been demonstrated in infants and children. Apply to the affected areas and rub in thoroughly. Apply to the affected areas and rub in thoroughly. 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